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Phase 2 clinical trials published in 2023 demonstrated unprecedented weight loss efficacy, with participants achieving up to 24.2% body weight reduction over 48 weeks results approaching those typically observed only with bariatric surgery[1]

Additionally, it has been demonstrated that IGF-I activated androgen receptor signaling in prostate cancer cells via the IGF-1R-forkhead box protein O1 (FOXO1) signaling axis, which is also implicated in castration-resistant prostate cancer (133135)

Most adverse effects were mild to moderate in severity, with no treatment discontinuations directly attributed to curcumin use

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