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Across all 19 drugs, measured against a standard scale of energy, pain, day-to-day function and mood, no drug produced a change large enough to count as a meaningful improvement at one year not tirzepatide, not semaglutide, not any of the rest

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"When you stop these low doses of these drugs, we don't know what's going to happen." On average, people will lose significantly less weight than they would with the maximum dose of a brand name version of the drug, McGowan agrees