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It was the first kind of drug which was used for diabetes treatment through the GLP-1 receptor. Over time, the scientists and the pharmaceutical industry figured out how to make synthetic GLP-1 last longer in the body through the use of other molecule agonists

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A 2025 systematic review and meta-analysis of 23 randomized controlled trials found that berberine reduced body weight by an average of about 0.88 kg, or roughly 2 pounds

Adzhubei, I., Jordan, D