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doi: 10.1016/j.cell.2016.11.018 12 LohJSMakWQTanLKSNgCXChanHHYeowSHet al

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This frontal area appears to have a role in the top-down and volitional regulation of affect, whereby it acts to suppress maladaptive emotional responses ( Decreased activity in the dorsolateral PFC in bipolar disorder may be associated with compromised working memory, impaired ability to sustain attention, and compromised executive function ( The ACC is located at the intersection of dorsal (predominantly cognitive) and ventral (mostly emotion-regulating) cerebral regions (116)