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Grouping: Control group (physiological saline intra-articular injection), AOD 9604 group (0.25mg/joint), hyaluronic acid (HA) group (0.5mg/joint), AOD 9604+HA combination group

Studies have examined its effects on fibroblast activity, extracellular matrix remodeling, antioxidant enzyme expression, and angiogenesis-related signaling pathways

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Motor functioning was evaluated starting at 2 weeks post-surgery and testing was conducted on a biweekly basis using a walking track analysis where the rats were made to walk in a confined walkway lined with white paper and led into a dark shelter