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18 The first step is to identify and stop the offending serotonergic medication(s), with supportive care to stabilise vital signs (maintenance of oxygen saturations, intravenous fluids, and continuous temperature cardiac monitoring), sedation with benzodiazepines (such as diazepam or midazolam), and in more severe cases, consideration of serotonin antagonists alongside muscle paralysis

Despite these advances, not everyone experiences the same success