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Celastrol, a widely used antioxidant drug, can reduce ROS accumulation by upregulating the Nrf2/GPX4 axis, thus significantly inhibiting ferroptosis of neurons and oligodendrocytes, thereby promoting the recovery of spinal cord tissue and motor function in rats with SCI

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Many people who supplement with glutathione notice immediate benefits to mental clarity and how they feel, but it may take longer (weeks or months) to replete glutathione levels into the optimal range, especially when deficient

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