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BACH1 itself is a direct transcriptional target of HIF1A, which binds its promoter under hypoxic conditions to induce expression 174 , highlighting a multilayered transcriptional network linking hypoxia, GSH metabolism, and cuproptotic vulnerability

A related drug, bremelanotide (Vyleesi), was later developed and approved for female hypoactive sexual desire disorder, but without the tanning side effects

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Additionally, Semaglutide GLP-1 injections are contraindicated in patients with a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2