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This fundamental chemical difference creates distinct metabolic effects and may produce different weight loss outcomes depending on individual genetics and baseline metabolism

examples include adalimumab, infliximab, and etanercept

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In 2024, the FDA expanded the label to include reducing the risk of major cardiovascular events in adults with established cardiovascular disease and overweight or obesity based on the SELECT trial, which randomized 17,604 patients and showed a 20% reduction in major adverse cardiovascular events over a mean 40 months