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When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

Despite its importance, many people suffer from vitamin D deficiency symptoms, such as chronic fatigue, muscle weakness, and a compromised immune system

And since having too much B12 isnt harmful (the body simply excretes the excess), its easier and cheaper to just get a shot (B12 injectables cost $14 apiece if bought online or $20 to $70 at a spa or doctors office)

Subsequently, for these data as well as the alpha diversity analyses, each treatment group (within each phylum or genus for the relative abundance data) was analyzed for normal distribution (ShapiroWilk test) and the data across groups were tested for homoscedasticity (BrownForsythe test)