Therefore, the fraction of drug that survives the first pass through the liver is simply (1 - E)
The SUSTAIN 29,30,31,32,33,34,35 and SCALE studies 10,11,12,13,14,15 have shown robust efficacy in lowering blood glucose levels in diabetic patients and inducing weight loss in obese patients over clinical trial periods ranging from 30 to 104 weeks
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