semaglutide weight gain Semaglutide, a second-generation GLP-1 receptor agonist, was associated with significantly reduced body and other metabolic factors in adults with schizophrenia, prediabetes, and overweight/obesity compared with placebo, research from September How to Stop Rebound Weight

While the study has limitations (retrospective, self-selected population, company-authored), having published peer-reviewed data is uncommon in this market

However, people who have established strong exercise habits (particularly resistance training) and high-protein dietary patterns during treatment tend to regain less

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Stopping the medication could mean regaining some, if not all, of the weight and the almost immediate return of food noise. But staying on these pricey drugs indefinitely can prove prohibitive