glp-1 receptor agonist fatigue management strategies Frontiers The Potential Indirect Impact of

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doi: 10.2337/db20-0856 46 GarciaCJKosekVBeltrnDToms-BarbernFAHajslovaJ

doi: 10.1186/s12967-024-05876-3 47 LiH.HeB.MaN.LiuC.CaiK.ZhangX.et al

In the murine model of lipopolysaccharide (LPS)induced ALI, severely impaired FAO in alveolar EpiCs participated in the inflammatory response and lung injury, which might be attributed to the decreased expression of key mediators involved in FAO, such as CPT1A, and could partly be counteracted by treatment with a PPAR agonist, fenofibrate ( CPT1A aggravated EC apoptosis and lung injury, while treatment with L-carnitine attenuated the pathological changes (Yao et al., 2019)