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[3] [4] These studies demonstrated that combination therapy can produce greater weight loss than monotherapy, supporting the general concept that complementary mechanisms may enhance outcomes

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It was suggested that patients with advanced melanoma who got nivolumab + ipilimumab or nivolumab alone had a higher percentage of sustained long-term survival rates and progression-free survival at 5 years than patients who were given ipilimumab alone, with no discernible decrease of quality of life in the nivolumab-containing regimens [206]

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