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When tested in musk shrews (a species that, unlike rodents, can vomit), TDN reduced weight without triggering emesis, while exendin-4 caused rapid, dose-dependent vomiting

The 1% concentration range used in most published clinical trials sits at the level demonstrated to produce dermal effects while maintaining a formulation viscosity optimized for absorption

This typically includes blood tests (full blood count, pregnancy test, and other tests if clinically indicated), pelvic ultrasound, and potentially endometrial sampling depending on age and risk factors

Listed below are the on-label (approved) uses and off-label (unapproved) uses